As the multi-mode fiber core diameter is much larger than single-mode fiber core diameter and the numerical aperture of multi-mode fiber is also larger than the numerical aperture of the single-mode fiber. Therefore, the coupling efficiency of multi-mode fiber to single-mode fiber is very low. In this paper, self-focusing lens was used to aggregate the beam of light which from the multi-mode fiber, and ball lens was used to reduce the divergence of the gathered beam. Without considering the premise of the connection loss, ZEMAX was used to calculate the coupling efficiency of multi-mode fiber to single-mode fiber. This new combination of lens-coupling method greatly improves the coupling efficiency, the maximum coupling efficiency can reach 38.7%. Therefore, this method is feasible.