The purpose of this application note is demonstrate the power and flexibility of the HI7188 to create a differential 64 channel A/D system. The HI7188 will perform all multiplexer switching control and calibration. This will enable the designer to perform a high precision 16-bit analog to digital conversion using one HI7188 sigma delta converter with up to sixty-four fully differential inputs. The 64 multiplexer channels are divided into 8 multiplexer blocks, with one block of 8 logical channels active at any given time. The conversion rate is 240 conversions per second per logical channel for each of the eight active channels. PGIA gain, unipolar/bipolar operation or calibration is on a per logical channel basis.