Many of today’s high-resolution ADCs (Analog-to-Digital Converters) are operating from a single supply and utilize fully differential inputs. This can be a problem for singleended signals that are bipolar relative to common. This article will illustrate circuit configurations that will preserve the full-scale input range by utilizing modern features, such as Programmable Gain Amplifiers (PGAs) and internal voltage reference. It will also discuss issues that the designer must consider when selecting components utilizing these signal-conditioning circuits.