High-energy particle accelerators are helping researchers investigate the nature of matter and the origins of the universe. Typical experiments involve carefully controlled collisions between either intersecting particle beams or a particle beam and an atomic-scale target. Subsequent analysis of the results may reveal new insights about the building blocks of matter and the forces that hold them together, answer questions about particles and dark matter, and provide clues about the formation of the universe more than 13 billion years ago. Creating particle collisions at nanometer scale and with picoseconds of duration requires extreme precision in spatial and temporal control. At facilities such as the European Organization for Nuclear Research, more commonly known as CERN, and the Australian Synchrotron, high-performance Agilent Acqiris digitizers are helping researchers achieve the levels of precision and control they need to perform more and better experiments in less time. Key attributes of the Agilent digitizers include high measurement throughput, very short “dead time” between acquisitions, excellent measurement fidelity, compact size and cost-effectiveness. The remainder of this note describes the creation of high-energy particle beams, the control of particle beams inside CERN’s Large Hadron Collider (LHC), and the control of electron beams that produce high-intensity light in the Australian Synchrotron. 1 A variety of additional references are included at the end of the note: These will help you learn more about these organizations, their facilities, the history of synchrotrons, and more.