Due to the complexity of JPEG2000,it was difficult to further improve its performance relied only on DSP and software.This paper proposed a design to achieve high-definition video compression system based on ADV212.The core of this design was ADV212.It took advantage of FPGA to achieve ADV212initialization control,data acquisition and auxiliary processing functions,then merged Luminance and Chrominance compressed data byte streams from two ADV212devices,generated a JPEG2000-compliant codestream jp2.The results show that the system is relatively DSP efficiency up10%~15%,with a small size,high image quality,compression signal easy to restore,and the compression ratio is adjustable.The system supports the SMPTE274M(1080i)video real-time encoding.