This user's guide describes the characteristics, operation, and use of the ADS1259EVM, both by itself and as part of the ADS1259EVM-PDK. This evaluation model (EVM) is an evaluation board for two different devices. First, it can be used to evaluate the ADS1259, a low-noise, 24-bit, single-channel, delta-sigma (ΔΣ) analog-to-digital converter (ADC). The ADS1259 can be used either in standalone applications or with the PGA280. The PGA280 is a high-precision instrumentation amplifier with digitally-controllable gain and signal integrity test capability. The combination of these two devices forms a high-resolution measurement system able to digitize a wide range of signals.